Comparative Effects of Plant Extract on Gastric Secretion

OBJECTIVE: To compare the effects of extracts from medicinal plants Ammi Visnaga & Olea eurpea on volume and acidity of stimulated gastric secretion in rabbits. METHODS: The present study was carried out in department of Pharmacology & therapeutics, Saidu Medical College Swat Pakistan between July 2008 to June 2009. Thirty rabbits weighing 1-1.5kg were included. They were divided in to groups A, B &C each having 10 animals. After fasting for 48 hours, pylorus of each animal was ligated. To group A Carbachol, group B extracts of Ammi visnaga and group C Olea europea followed by Carbachol after 15 minutes to groups B & C were administered intraperitoneally. After 4 hours, stomach was removed, volume was measured, contents centrifuged & estimation for acidity was done by method of titration. Data was subjected to statistical analysis. RESULTS: In groups B & C, reduction in volume, free and total acidity of gastric juice was observed. All these reductions were found statistically highly significant when their means were compared with that of group A (P <0.001). CONCLUSION: Extracts can be used effectively in the treatment of hyper acidity conditions and peptic ulcer after evaluation of their effects in human being.